The use of insecticidal bed nets (IBNs) to prevent mosquito bites in malaria-endemic communities can result in resistance developing in secondary pests like bed bugs, according to research published in Parasites and Vectors. Decreased efficacy against bed bugs and other non-mosquito pests may result in misuse of both mosquito adulticides and bed nets, hampering efforts to stop the spread of malaria and other insect-borne disease. With resistance following a predicable pattern in both disease-transmitting and secondary pests, there is a critical need to embrace safer, nonchemical solutions, including both ecological and structural approaches to pest management.